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Using a sample pediatric case study (Rosa), this video describes how autoantibody screening can enable early detection of presymptomatic T1D, providing a window of opportunity to prepare for clinical diagnosis

Rosa is an 8-year-old child with presymptomatic autoimmune T1D, but neither she nor her family know this yet. Without prior knowledge, she may be at increased risk of DKA at clinical onset of T1D

People positive for at least one islet autoantibody should be monitored regularly

People identified early through screening programs have milder disease and better quality of life compared to control

Explore the association of GWAS and GRS and how they can improve T1D

GRS helps to select individuals at high risk for T1D for screening

T1D has three different stages, characterized by increasing loss of beta-cell function

CD8+ T cell exhaustion rate predicts progression of T1D

The number, type, and titer of islet autoantibodies detected in T1D screening tests provide valuable information about potential progression to clinical T1D. 

Explore how clinical outcomes are impacted by screening and monitoring

Overview of the factors playing a role in the etiology of T1D.

A guide to autoimmune type 1 diabetes (T1D) screening tests.