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Implications for Children Diagnosed at Clinical Onset of T1D Without Early Identification

Potential Implications for Children Diagnosed at Clinical Onset of T1D Stage 3

Rosa is an 8-year-old child with presymptomatic autoimmune T1D, but neither she nor her family know this yet. Without prior knowledge, she may be at increased risk of DKA at clinical onset of T1D

Autoantibody Screening Can Detect Presymptomatic Autoimmune T1D in Children

Autoantibody Screening Can Detect Presymptomatic Autoimmune T1D in Children

Using a sample pediatric case study (Rosa), this video describes how autoantibody screening can enable early detection of presymptomatic T1D, providing a window of opportunity to prepare for clinical diagnosis

Autoimmune T1D Imposes a Psychosocial Burden on Affected Children and Their Carers

Autoimmune T1D Imposes a Psychosocial Burden on Affected Children and Their Carers

Early identification of presymptomatic autoimmune T1D may reduce the psychological burden experienced at diagnosis by giving time for preparation and education

Staging in T1D

Staging in T1D

T1D has three different stages, characterized by increasing loss of beta-cell function

The Role of GWAS and GRS in T1D

The role of GWAS and GRS in T1D

Explore the association of GWAS and GRS and how they can improve T1D

The Impact of GRS on T1D Screening

The impact of GRS on T1D screening

GRS helps to select individuals at high risk for T1D for screening

CD8+ T cell Exhaustion as T1D Biomarker

CD8+ T cell Exhaustion as T1D Biomarker

CD8+ T cell exhaustion rate predicts progression of T1D

Exploring Guidance for Monitoring

Guidance for Monitoring

People positive for at least one islet autoantibody should be monitored regularly

What Are the Benefits of Screening?

Benefits of Screening

People identified early through screening programs have milder disease and better quality of life compared to control

Islet Autoantibodies in T1D

Islet Autoantibodies in T1D

The number, type, and titer of islet autoantibodies detected in T1D screening tests provide valuable information about potential progression to clinical T1D. 

Monitoring Individuals with IAb Positive Status

Monitoring Individuals with IAb Positive Status

Explore how clinical outcomes are impacted by screening and monitoring

Exploring the Etiology of Autoimmune Type 1 Diabetes

Exploring the Etiology of Autoimmune Type 1 Diabetes

Overview of the factors playing a role in the etiology of T1D.