- Faculty
- BR1DGE
Richard Oram
NIHR Exeter Clinical Research Facility Exeter, UK
The potential to identify pre-clinical type 1 diabetes is a game-changing moment in the field, and one that could directly benefit the many people who develop type 1 diabetes.
Professor Richard Oram is a clinician scientist with a record in bringing original ideas and approaches to type 1 diabetes research. His contributions include paradigm-shifting studies of beta-cell function, highlighting persistence of endogenous insulin in many with longstanding type 1 diabetes (T1D). Prof. Oram developed a type 1 diabetes genetic risk score (T1D GRS) that has rapidly been integrated into clinical care for classification of diabetes, with potential field changing impacts on type 1 diabetes population screening. In parallel, his study of extremely early onset T1D in babies is revealing novel insights about genetic, immune and phenotypic factors associated with very early onset diabetes, with critical advances relating to the role of beta-cell stress, and immune checkpoints in causality of autoimmunity.
